|
KMID : 1007320100160010039
|
|
Journal of the Korean Society of Menopause
2010 Volume.16 No. 1 p.39 ~ p.45
|
|
|
The Effect of Pomegranate on Depression, Anxiety, and Food Intake in Ovariectomized Rats
|
|
Ahn Ki-Hoon
Yi Kyong-Wook
Park Hyun-Tae
Shin Jung-Ho
Hur Jun-Young
Kim Young-Tae
Kim Sun-Haeng
Lee Kyu-Wan
Kim Seung-Hee
Bae Chun-Sik
Kim Tak
|
|
|
Abstract
|
|
|
Objectives: To determine whether or not pomegranate extract can affect depression, anxiety, and food intake in ovariectomized rats.
Methods: Seventy-nine female Sprague-Dawley rats were divided into six groups: A, no operation and no drug intake; B, sham operation and distilled water; C, ovariectomy and distilled water; D, ovariectomy and 10% dilute pomegranate extract; E, ovariectomy and 20% dilute pomegranate extract; and F, ovariectomy and 40% dilute pomegranate extract. Beginning 2 days after surgery, drugs were administrated for 4 weeks. After that, the rats were subjected to the elevated plus maze (EPM) test and forced swim test (FST).
Results: The 10% pomegranate extract had a lower % closed arm entry frequency in the EPM test. A pomegranate dose-dependent decrease in the duration of immobility duration in FST was shown. Pomegranate did not reverse ovariectomy-related hyperphagia and weight gain.
Conclusion: Pomegranate extract improved depression and anxiety in a postmenopausal model with ovariectomized rats.
|
|
|
KEYWORD
|
|
|
Pomegranate, Depression, Anxiety, Food intake
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|